Author: Dr Noaman Saeed Khattak
Discovery of Four-Stranded DNA Structure in Human Cells: A Breakthrough in Science Dr. Muhammad Noaman Saeed Khattak For decades, scientists have studied DNA as the iconic double-helix structure that serves as the blueprint of life. But recent research has revealed something extraordinary—an alternative DNA structure, known as G-quadruplex, has been observed forming naturally inside human cells for the first time. This discovery, made possible by cutting-edge fluorescence imaging technology, challenges our fundamental understanding of DNA and opens new doors for the treatment of diseases like cancer. The four-stranded G-quadruplex DNA is a rare structure, formed by guanine-rich sequences that stack…
Your Trusted Medical Center in G-8 Markaz, Islamabad – Comprehensive Healthcare Under One Roof 📍 Location: G-8 Markaz, Islamabad 📞 Contact Us: 0334-8688933 | 0331-1110675 🌐 Visit Our Website: www.saeedhospital.com ⸻ 🏥 Introduction: Islamabad’s Premier Multispecialty Hospital Saeed International Hospital is a state-of-the-art medical facility offering comprehensive healthcare services under one roof. Located in G-8 Markaz, Islamabad, we are committed to providing world-class patient care, advanced diagnostics, and specialized treatments across multiple medical disciplines. With a team of highly qualified doctors, specialists, and advanced medical technology, we ensure the best possible healthcare solutions for our…
Dr. Muhammad Noaman Saeed Khattak Education is the backbone of any progressive society, but when it falls prey to corruption, cheating, and deception, the future of an entire generation is put at stake. In Khyber Pakhtunkhwa, particularly in Karak, private educational institutions have turned cheating into a well-organized business, completely undermining the transparency of the examination system. This deeply rooted network involves private schools, examination staff, parents, and even some corrupt officials within the educational boards. The issue is worsening day by day, becoming a significant cause of educational destruction in the region. Many students who are originally studying…
*Introduction:* Regenerative medicine has revolutionized the way we approach disease treatment. Traditional embryonic stem cells have been plagued by ethical controversy. However, endosomal-derived embryonic stem cells (ESCs) offer an exciting alternative. *Production:* ESCs are derived from endosomes, which are present in all cells. The derivation process involves specific culture conditions and growth factors to induce embryoid body formation and subsequent stem cell-like cells. *Applications:* ESCs have vast potential in regenerative medicine: – Tissue engineering – Cell therapy – Organ regeneration They can also be used in drug discovery, testing new drugs and therapies. Endosomal-derived embryonic stem cells have the potential…
The teratoma formation assay is a widely used and well-established method for assessing the pluripotency and self-renewal capacity of stem cells, particularly embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) (1, 2). This assay has a long history, dating back to the 1970s, and has been widely adopted as a gold standard for assessing pluripotency in stem cell research (3). _History of the Teratoma Formation Assay_ The teratoma formation assay was first used to study the developmental potential of embryonal carcinoma cells (4). Since then, it has been widely adopted as a method for assessing pluripotency in stem…
Abstract: Acute lung injury (ALI) is a severe and life-threatening condition characterized by inflammation, oxidative stress, and tissue damage. Despite advances in medical care, ALI remains a significant cause of morbidity and mortality. Mesenchymal stem cells (MSCs)-derived extracellular vesicles (EVs) have emerged as a promising therapeutic tool for ALI. This review aims to provide a comprehensive overview of the current understanding of MSCs-derived EVs in ALI, including their mechanisms, therapeutic potential, and future directions. Introduction: ALI is a complex and heterogeneous condition, involving various cellular and molecular mechanisms (1). The current treatment options for ALI are limited, and new…
Abstract: G-protein-coupled receptors (GPCRs) play a crucial role in various skin diseases, including dermal injuries, chronic inflammatory dermatoses, and cutaneous malignancies. Recent advances in genetic, signal transduction, and structural studies have significantly enhanced our understanding of cutaneous GPCR functions. This review provides a comprehensive overview of recent discoveries of pathogenic GPCRs in skin diseases and discusses targeting of cutaneous GPCR complexes via the transient receptor potential (TRP) channel and structure elucidation. We also highlight the development of potent potential drugs and future directions for therapeutic targeting of GPCRs involved in skin disorders. Introduction: G-protein-coupled receptors (GPCRs) are a vast family…
_Introduction_ Erectile dysfunction (ED) is a common condition that affects millions of men worldwide. Despite available treatments, many patients remain unsatisfied with current therapies. However, recent research suggests that stem cell therapy may be a promising new approach for ED treatment (1). _The Science Behind Stem Cell Therapy_ Stem cell therapy involves the use of stem cells to promote tissue repair and regeneration. In the context of ED, stem cells have been shown to improve erectile function by promoting smooth muscle regeneration and angiogenesis (2). _The Study_ A recent study published in the Journal of Sexual Medicine (Vol. 15,…
Abstract: Synucleinopathies, a group of neurodegenerative disorders characterized by the accumulation of alpha-synuclein protein, have been the focus of intense research in recent years. While the exact mechanisms underlying these diseases remain unclear, emerging evidence suggests that erythrocytes, or red blood cells, may play a crucial role in their development and progression. This review aims to summarize the current state of knowledge on the involvement of erythrocytes in synucleinopathies, highlighting their potential as a therapeutic target. Introduction: Synucleinopathies, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, are characterized by the accumulation of alpha-synuclein protein in the…
Dr Noaman Saeed Khattak, CEO, Saeed International Hospital, Islamabad. nskhattak@hotmail.com 03348688933 Stem cells are undifferentiated cells that have the ability to develop into different cell types, making them a promising tool for various medical applications. There are several types of stem cells, including: – Embryonic stem cells: Derived from embryos and have the ability to develop into any cell type – Adult stem cells: Found in adult tissues and have a limited ability to develop into different cell types – Induced pluripotent stem cells: Generated from adult cells and have the ability to develop into any cell type -…