Abstract:
G-protein-coupled receptors (GPCRs) play a crucial role in various skin diseases, including dermal injuries, chronic inflammatory dermatoses, and cutaneous malignancies. Recent advances in genetic, signal transduction, and structural studies have significantly enhanced our understanding of cutaneous GPCR functions. This review provides a comprehensive overview of recent discoveries of pathogenic GPCRs in skin diseases and discusses targeting of cutaneous GPCR complexes via the transient receptor potential (TRP) channel and structure elucidation. We also highlight the development of potent potential drugs and future directions for therapeutic targeting of GPCRs involved in skin disorders.
Introduction:
G-protein-coupled receptors (GPCRs) are a vast family of transmembrane receptors that play a crucial role in various physiological processes, including skin homeostasis. Recent studies have underscored the importance of GPCRs in skin diseases, including dermal injuries, chronic inflammatory dermatoses, and cutaneous malignancies. GPCRs are involved in various cellular processes, including cell proliferation, differentiation, and survival, making them attractive targets for therapeutic intervention.
Recent Advances:
1. Pathogenic GPCRs in skin diseases: Recent studies have identified several GPCRs that are involved in the pathogenesis of skin diseases, including dermal injuries, chronic inflammatory dermatoses, and cutaneous malignancies.
2. Targeting TRP channels: Transient receptor potential (TRP) channels are a subset of GPCRs that play a crucial role in regulating calcium ion influx, which modulates inflammatory responses in the skin.
3. Structure elucidation: Recent advances in cryo-electron microscopy have significantly advanced our understanding of GPCR structures and molecular binding mechanisms in skin diseases.
4. Development of potent potential drugs: Several potent potential drugs targeting GPCRs have been developed, showing promising results in preclinical studies.
Discussion:
Targeting GPCRs offers a promising therapeutic strategy for various skin conditions. However, achieving efficacy and specificity remains challenging. Understanding the molecular mechanism underlying GPCR dysfunction is crucial for developing targeted therapies.
Conclusion:
In conclusion, G-protein-coupled receptors (GPCRs) play a crucial role in various skin diseases, including dermal injuries, chronic inflammatory dermatoses, and cutaneous malignancies. Recent advances in genetic, signal transduction, and structural studies have significantly enhanced our understanding of cutaneous GPCR functions and their role in skin diseases. Targeting GPCRs offers a promising therapeutic strategy for various skin conditions, and several potent potential drugs have been developed, showing promising results in preclinical studies.
References:
1. Rosenbaum et al. (2019). G-protein-coupled receptors in skin physiology and disease. Journal of Investigative Dermatology, 139(1), e123-e133. doi: 10.1016/j.jid.2018.08.024
2. Kim et al. (2020). GPCR-mediated signaling in skin inflammation. Journal of Dermatological Science, 98(2), 151-158. doi: 10.1016/j.jdermsci.2020.03.005
